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Updated: Sep 19, 2025
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
The role of inflammatory parameters in predicting acute complicated diverticulitis
Fırat Canlıkarakaya1, Serhat Ocaklı2, İbrahim Doğan3
1General Surgery, Amasya University Faculty of Medicine, Amasya, Türkiye.
Aim:
Acute diverticulitis is an inflammatory process associated with pericolonic inflammation involving one or more colonic diverticula and is usually classified as uncomplicated or complicated.
Method:
This multicenter study retrospectively examined the data of 135 patients who received inpatient treatment for diverticulitis in two tertiary hospitals. Some inflammation scores were calculated with the data obtained from the patients' Complete blood count(CBC) and biochemical laboratory results, and the power of these scores in predicting complicated diverticulitis was examined.
Results:
A total of 135 patients (57 men and 78 women) were included in this study. In the ROC analysis performed to evaluate the effectiveness of predicting complications, the CRP/Albumin(CAR) score was found to be significant (AUC: 0.762, p = 0.001). For a cutoff value > 0.25, CAR predicted complications with 73% sensitivity and 76% specificity (AUC: 0.762, p = 0.001).
Conclusion:
Determining the severity of the disease by differentiating complicated from uncomplicated cases will contribute to reducing hospital stay times and related costs. Our study showed that CAR score can be used as a reliable, inexpensive, and rapid marker for predicting complicated diverticulitis in acute diverticulitis.
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