Hepatoprotective mechanisms of ginkgo-Biloba and dandelion extracts: antioxidant activity and modulation of TNF-α and P53 pathways in Thioacetamide-induced liver injury
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View abstract on PubMed
Summary
This summary is machine-generated.Ginkgo biloba and dandelion extracts protect against thioacetamide-induced liver injury in rats. These natural compounds exhibit antioxidant, anti-inflammatory, and anti-apoptotic properties, reducing liver damage and improving biochemical markers.
Area Of Science
- Toxicology and Pharmacology
- Natural Product Research
- Hepatology
Background
- Chemical and pharmaceutical toxins are a growing cause of liver injuries.
- Thioacetamide (TAA) is a widely used chemical inducer for creating experimental liver injury models.
- Oxidative stress, inflammation, and apoptosis are key mechanisms in TAA-induced hepatotoxicity.
Purpose Of The Study
- To evaluate the hepatoprotective potential of Ginkgo biloba and dandelion extracts against TAA-induced liver injury in a rat model.
- To investigate the underlying mechanisms, including antioxidant, anti-inflammatory, and anti-apoptotic effects.
Main Methods
- Male albino rats were divided into four groups: control, TAA-induced liver injury, TAA + Ginkgo biloba extract, and TAA + dandelion extract.
- Hepatoprotective effects were assessed by measuring serum liver enzymes, bilirubin, lipid profiles, and total protein/albumin levels.
- Oxidative stress markers (malondialdehyde, glutathione) and histopathological changes were evaluated.
- Immunohistochemistry was used to assess the expression of TNF-α and P53.
Main Results
- TAA administration significantly elevated liver enzymes, bilirubin, cholesterol, and triglycerides, while decreasing total protein and albumin.
- TAA induced significant oxidative stress, evidenced by increased malondialdehyde and decreased glutathione.
- Co-treatment with Ginkgo biloba (100 mg/kg) or dandelion (500 mg/kg) extracts significantly ameliorated these biochemical and oxidative stress markers.
- Histopathology revealed reduced necrosis, fibrosis, and inflammation in treated groups. Ginkgo biloba showed slightly more potent effects.
- Reduced expression of TNF-α and P53 proteins was observed in the treated groups, indicating anti-inflammatory and anti-apoptotic actions.
Conclusions
- Ginkgo biloba and dandelion extracts demonstrate significant hepatoprotective effects against TAA-induced liver injury in rats.
- The protective mechanisms involve antioxidant, anti-inflammatory, and anti-apoptotic activities.
- These findings support the therapeutic potential of Ginkgo biloba and dandelion for managing drug- and toxin-induced liver damage.
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