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Updated: Jun 12, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

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A review of conjugation technologies for antibody drug conjugates

Qirui Fan1, Hu Chen1, Guoguang Wei1

  • 1Department of Discovery & Development, WuXi XDC Co., Ltd, 520 Fute North Road, Pilot Free Trade Zone, Pudong New Area, Shanghai, 200131, China.

Antibody Therapeutics
|June 10, 2025
PubMed

Keywords:
affinity peptide conjugationantibody–drug conjugate (ADC)cysteine conjugationenzymatic-tag conjugationglycan remodeling conjugationlysine conjugationnon-canonical amino acids (ncAAs) conjugation

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