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Piperacillin-Tazobactam-Induced Generalized Exanthematous Pustulosis
Sudeep Chapagain1, Prabina Basnet1, Surendra Khanal1
1Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Cureus
|June 10, 2025
Summary
Acute generalized exanthematous pustulosis (AGEP), a rare antibiotic reaction, presents with pustules and erythema. This case highlights piperacillin-tazobactam as a trigger, with symptoms resolving after drug cessation.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare, severe cutaneous adverse reaction.
- Antibiotics, particularly beta-lactams, are the most common causative agents.
- AGEP is characterized by widespread sterile pustules on an erythematous background.
Observation:
- A 58-year-old female developed AGEP following piperacillin-tazobactam administration.
- Clinical presentation included rapid onset of sterile pustules, swelling, and erythema.
- Histopathology confirmed neutrophilic pustules and eosinophilic infiltration.
Findings:
- Piperacillin-tazobactam was identified as the likely trigger for AGEP.
- Discontinuation of the antibiotic led to symptom resolution.
- Skin lesions resolved via desquamation within three days of drug cessation.
Implications:
- This case underscores the importance of recognizing AGEP in patients exposed to piperacillin-tazobactam.
- Prompt diagnosis and withdrawal of the offending agent are crucial for managing AGEP.
- Understanding drug-induced AGEP aids in preventing severe cutaneous reactions.
Keywords:
acute generalized exanthematous pustulosisbeta-lactambeta-lactam antibioticscutaneous drug reactionfeverpiperacillin-tazobactamMore Related Videos
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