A Case of a CRTC1::TRIM11 Cutaneous Tumor With Venous and Lymphatic Invasion and Lymph Node Metastasis
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View abstract on PubMed
Summary
This summary is machine-generated.A rare CRTC1::TRIM11 cutaneous tumor (CTCT) was diagnosed in a young woman. This case highlights the importance of comprehensive diagnostics for this novel entity and suggests potential for targeted therapies.
Area Of Science
- Dermatological Oncology
- Surgical Pathology
- Molecular Diagnostics
Background
- The CRTC1::TRIM11 cutaneous tumor (CTCT) is a newly identified and uncommon neoplasm.
- Accurate diagnosis is crucial for appropriate patient management and prognosis.
Observation
- A 29-year-old woman presented with a thigh nodule initially suspected as a fibrohistiocytic tumor.
- Histopathology and immunohistochemistry revealed complex features, including S-100, SOX10, and TRIM11 positivity.
- No EWSR1 gene rearrangement was detected via fluorescence in situ hybridization.
Findings
- The final diagnosis was CTCT, confirmed by extensive immunohistochemical analysis.
- The primary tumor exhibited partial invasion, venous and lymphatic invasion, and metastasis to the inguinal lymph node.
- Metastasis was confirmed through PET/CT imaging and excisional biopsy.
Implications
- Surgical resection is the primary treatment, but adjuvant therapy guidelines are lacking.
- Targeted therapies directed at the CRTC1::TRIM11 fusion gene represent a promising future treatment avenue.
- Further research is essential to understand CTCT biology and optimize treatment strategies.
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