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Penile Abscess Complicating Chronic Penile Calciphylaxis in a Heart Transplant Recipient and End-Stage Renal Disease
Bharath P Bhushan1, Sharath Rajagopalan1, Vikash Kumar1
1Internal Medicine, West Virginia University, Morgantown, USA.
Insights
Calciphylaxis, a rare condition causing tissue death, is particularly dangerous in end-stage renal disease patients. This case highlights the extreme rarity and high mortality risk of penile calciphylaxis and its management challenges.
Area of Science:
- Nephrology
- Dermatology
- Vascular Biology
Background:
- Calciphylaxis, or calcific uremic arteriolopathy, is a severe condition causing skin necrosis due to arteriolar calcification.
- It predominantly affects patients with end-stage renal disease (ESRD), carrying a high mortality rate exceeding 50% within one year.
- Penile calciphylaxis is an exceptionally rare manifestation with significant associated mortality and diagnostic/therapeutic difficulties.
Abstract:
Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare but severe and life-threatening condition that is characterized by cutaneous arteriolar calcification and subsequent tissue necrosis. Calciphylaxis is more commonly seen in patients with end-stage renal disease (ESRD) and has a one-year mortality of greater than 50%. Penile calciphylaxis is extremely rare and carries a high mortality risk. Oftentimes, diagnosis and treatment are challenging. We present a case of a 71-year-old heart transplant recipient and end-stage renal disease patient with a history of chronic penile calciphylaxis who developed penile abscesses, highlighting the challenges of managing this complicated condition.
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