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Updated: Jun 14, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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YAP, TAZ, and Hippo-Dysregulating Fusion Proteins in Cancer

Jordan H Driskill1,2, Josephine K Dermawan3,4, Cristina R Antonescu3

  • 1Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Annual Review of Cancer Biology
|June 10, 2025
PubMed
Summary

Gene fusions involving YAP1 or WWTR1 drive cancers and are therapeutic targets. This review explores these oncoproteins, their mechanisms, and vulnerabilities, offering a framework to predict oncogenic potential.

Keywords:
Hippo pathwayWWTR1/TAZYAP1cancergene fusionssarcoma

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