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Updated: Sep 19, 2025

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Synthetic methodologies to access skipped dienes: a focus on the catalytic systems
Polyssena Renzi1, Alberto Lanfranco1, Lucia Pazderová1
1Department of Chemistry, University of Turin, Via Giuria 7, 10125 Turin, Italy. polyssena.renzi@unito.it.
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1,4-Dienes, also known as skipped dienes, are widely diffused in natural products and serve as valuable synthetic intermediates. However, their synthesis continues to pose a substantial challenge. In recent years, there has been a notable development in the field, with the emergence of highly stereoselective methodologies for the construction of the 1,4-diene moiety. This review discusses the latest advances in the synthesis of skipped dienes, with a particular emphasis on the catalytic system and reaction mechanism. Metal-mediated (Ru, Co, Rh, Ir, Ni, Pd, Cu, Au, Ca, Ti, Cr, Yb), metal-free and organocatalyzed transformations as well as synergistic/dual and metallaphotoredox-catalysed reactions, published in the last five years, are reported.
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