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Updated: May 12, 2026

Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
Published on: August 28, 2009
Turn-On Luminescent Detection of Liver Cancer Biomarker β-Glucuronidase Using a Terbium-Based Paper Sensor
Shruthi Sakthivel1, Ananya Biswas1, Uday Maitra1
1Department of Organic Chemistry, Indian Institute of Science, Bengaluru, Karnataka, 560012, India.
Abstract:
We report the first turn-on lanthanide luminescent probe for time-gated detection of liver cancer biomarker β-glucuronidase. This innovative assay offers unprecedented rapidity, simplicity, and sensitivity, requiring minimal sample volumes and boasting exceptionally low detection limits (LOD of 40 ng/mL). The protocol was simplified and made "instrument-free" by developing TbCh gel-immobilized paper sensors and measuring the luminescence response after enzyme addition using ImageJ software.

