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Structural Protein Function

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Updated: Sep 19, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Re-Understanding Silk Aggregates as Bioactive Agents.

Shengnan Fu¹, Fan C Wang², Qiyuan Song¹

¹Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215000, People's Republic of China.

ACS Applied Materials & Interfaces

|June 10, 2025

Summary

This summary is machine-generated.

Engineered silk nanofiber aggregates (BSNFs) show enhanced bioactivity compared to other silk forms. Their unique nanostructure improves cellular uptake, promoting proliferation, migration, and skin barrier repair for advanced biomaterials.

Keywords:

aggregates bioactive agents cosmetics silk fibroin tissue regeneration

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Last Updated: Sep 19, 2025

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Silk Film Culture System for in vitro Analysis and Biomaterial Design

Silk Film Culture System for in vitro Analysis and Biomaterial Design

Published on: April 24, 2012

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Silk fibroin (SF) is a widely used structural biomaterial.
Its inherent bioactive potential for material design is largely unexplored.
Bioactive agents are crucial for biomedical product performance.

Purpose of the Study:

To develop and characterize β-sheet-rich silk nanofiber aggregates (BSNFs).
To compare the bioactivity of BSNFs with amorphous SF solution (ASF) and recombinant SF (RSF).
To investigate the influence of conformation and nanostructure on silk fibroin bioactivity.

Main Methods:

Fabrication of BSNFs with controlled diameters (~20 nm) via bioinspiration.
Systematic comparison of BSNFs, ASF, and RSF in cellular assays.
Evaluation of antioxidant capacity, cellular proliferation, migration, anti-inflammatory effects, and skin barrier protection.

Main Results:

BSNFs and RSF showed enhanced cellular antioxidant activity via improved phagocytic uptake.
Nanofibrous structure and β-sheet conformation improved intracellular bioactivity.
BSNFs demonstrated superior cellular proliferation, migration, anti-inflammatory effects, and skin barrier protection compared to ASF and RSF.

Conclusions:

Silk fibroin aggregates can be inherently bioactive, with nanostructure modulating activity.
This redefines SF's role beyond structural applications.
Provides a rational design for next-generation functional silk biomaterials with enhanced bioactivities.