Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

2.0K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonization of slice thickness through resampling improves comparability of MRI-derived neonatal brain volumes.

Frontiers in radiology·2026
Same author

Feasibility and acceptability of a guided internet-based acceptance and commitment therapy intervention (MobACT) for adults with chronic pain in Italy: A pilot mixed-methods randomized controlled trial.

Internet interventions·2026
Same author

Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.

JAMA network open·2026
Same author

Intraoperative Evaluation of Semiautomatic Localization of the Facial Nerve Using Diffusion Tensor Imaging in Patients with Large Vestibular Schwannomas: A Pilot Study.

Journal of neurological surgery reports·2026
Same author

Application of artificial intelligence in paediatric oncology imaging.

Pediatric radiology·2026
Same author

What needs to be standardized for reliable, reproducible, and robust tractography?

GigaScience·2026

Related Experiment Video

Updated: May 5, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K

Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric

Cyrano Chatziantoniou1,2, Roelof van Ewijk3, Madeleine Adams4

  • 1University Medical Center Utrecht, Utrecht, Heidelberglaan 100, 3584 CX, Netherlands. c.chatziantoniou-3@umcutrecht.nl.

Pediatric Radiology
|June 10, 2025
PubMed
Summary

Multicenter diffusion-weighted imaging for pediatric rhabdomyosarcoma shows acquisition parameter variability. Standardizing the highest b-value is crucial for consistent apparent diffusion coefficient (ADC) measurements over time.

Keywords:
AdolescentChildDiffusion magnetic resonance imagingRhabdomyosarcoma

More Related Videos

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.3K
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
10:25

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

1.7K

Related Experiment Videos

Last Updated: May 5, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.3K
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
10:25

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

1.7K

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) shows promise as a biomarker for pediatric rhabdomyosarcoma treatment response.
  • Multicenter studies are necessary due to the rarity of this cancer, but introduce variability in imaging acquisition parameters.

Purpose of the Study:

  • To assess how varying acquisition parameters influence ADC estimates in a multicenter rhabdomyosarcoma patient dataset.
  • To identify critical parameters affecting ADC measurements in pediatric rhabdomyosarcoma.

Main Methods:

  • Analysis of 195 scans from 114 pediatric and adolescent rhabdomyosarcoma patients across 22 centers.
  • Evaluation of the impact of voxel size, b-values, and echo time on tumor ADC values.
  • Specific investigation into the effect of the highest b-value on a subset of scans.

Main Results:

  • Significant variability in acquisition parameters was observed across the cohort and individual centers.
  • No single parameter significantly affected cross-sectional ADC estimates when corrected for multiple comparisons.
  • A decrease in the highest b-value reduced ADC by 2.8% per 100 s mm⁻²; differing b-values between baseline and follow-up scans altered longitudinal ADC (P<0.05).

Conclusions:

  • Despite wide variations in acquisition parameters, cross-sectional tumor ADC did not show significant differences.
  • Changes in the highest b-value between baseline and follow-up scans can impact longitudinal ADC estimates.
  • Maintaining a constant highest b-value is recommended for consistent longitudinal ADC assessment in rhabdomyosarcoma studies.