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Related Experiment Videos

Trabeculo-electropuncture in cynomolgus monkeys (Macaca irus).

F Hoffmann, J P Harnisch, A Bill

    Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe'S Archive for Clinical and Experimental Ophthalmology
    |March 29, 1977
    PubMed
    Summary
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    Trabeculo-electropuncture (TEP) did not improve aqueous humor outflow in monkeys. Scar tissue formation in Schlemm's canal after TEP or probe insertion blocked drainage, negating any potential benefits.

    Area of Science:

    • Ophthalmology
    • Glaucoma Research
    • Surgical Innovation

    Background:

    • Glaucoma management often involves procedures to enhance aqueous humor outflow.
    • Trabeculo-electropuncture (TEP) is a minimally invasive technique explored for glaucoma treatment.
    • Understanding the histopathological effects of TEP is crucial for evaluating its efficacy.

    Purpose of the Study:

    • To investigate the long-term effects of Trabeculo-electropuncture (TEP) on aqueous humor outflow and Schlemm's canal anatomy in cynomolgus monkeys.
    • To determine the histopathological changes induced by TEP and probe insertion in the anterior segment of the eye.

    Main Methods:

    • Trabeculo-electropuncture (TEP) was performed on one eye of ten cynomolgus monkeys.
    • Control eyes underwent sham procedures, including probe insertion without discharge or no probe insertion.

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  • Aqueous humor outflow facility was measured preoperatively and at 2, 6, and 18 weeks postoperatively.
  • Gonioscopy, light microscopy, and electron microscopy were used to assess anatomical and cellular changes.

    • Main Results:

    • TEP did not produce lasting improvements in aqueous humor outflow facility.
    • Gonioscopy revealed significant anatomical alterations in Schlemm's canal in TEP-treated and sham-probe eyes.
    • Histological examination showed dense scar tissue formation occluding Schlemm's canal and replacing the trabecular meshwork in treated and sham-probe eyes.

    Conclusions:

    • The failure of TEP in this model is attributed to the formation of dense scar tissue.
    • Scar tissue development within Schlemm's canal obstructs aqueous humor outflow pathways.
    • Probe insertion, with or without electro-puncture, can induce detrimental scarring, limiting the therapeutic potential of TEP.