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Updated: Jan 18, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Published on: September 20, 2016

Prognosis, imaging characteristics, and clinicopathological features of heavy smokers with clinical stage I lung

Ikki Takada¹, Yoshihisa Shimada², Takahiro Mimae³

¹Department of Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 161-0032, Japan.

General Thoracic and Cardiovascular Surgery

|June 10, 2025

Summary

Smoking extent significantly impacts survival and tumor characteristics in early-stage lung adenocarcinoma. Heavy smokers face poorer outcomes, with age and vascular invasion worsening prognosis.

Keywords:

Adenocarcinoma Heavy smoker Prognostic factor SUVmax Smoking extent

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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Published on: March 17, 2020

Area of Science:

Oncology
Pulmonary Medicine
Radiology

Background:

Lung adenocarcinoma (LDA) is a major cause of cancer mortality.
Understanding factors influencing prognosis in early-stage LDA is crucial for treatment planning.

Purpose of the Study:

To investigate the association between smoking extent and prognosis, imaging features, and clinicopathological factors in clinical stage I lung adenocarcinoma (c-stage I LDA).

Main Methods:

Analysis of 2,285 patients with c-stage I LDA who underwent surgical resection (2010-2018).
Classification into never, light (Brinkman Index [BI] 0-600), and heavy smokers (BI > 600).
Evaluation of clinicopathological features, imaging characteristics (solid proportion, SUVmax), and overall survival (OS).

Main Results:

Significant differences in OS were observed across smoking groups.
Heavy smokers showed more invasive imaging characteristics (larger solid proportion, higher SUVmax).
Heavy smoking (HR 2.071), older age (HR 1.111), and vascular invasion (HR 2.312) were independently associated with poorer OS.

Conclusions:

Smoking extent is an independent predictor of poorer survival, larger solid tumor size, and higher SUVmax in c-stage I LDA.
Age and vascular invasion are significant prognostic factors, especially in heavy smokers.