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Factors associated with chronic opioid use after minimally invasive lung resections.

Isabel Emmerick¹, Hayley Reddington¹, Tanmay N Patil¹

¹University of Massachusetts Chan Medical School, Department of Surgery, Worcester, Massachusetts, United States of America.

|June 10, 2025

Summary

This summary is machine-generated.

Higher pre-discharge opioid doses predict chronic opioid use after minimally invasive lung resections. This finding highlights the need for strategies to reduce opioid consumption in patients undergoing thoracic surgery.

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Area of Science:

Thoracic Surgery
Pain Management
Opioid Stewardship

Background:

Minimally invasive lung resections (MILR) can lead to persistent postoperative pain.
Patients undergoing MILR face a significant risk of developing chronic postoperative opioid use.

Purpose of the Study:

To identify factors associated with chronic opioid usage following MILR.
To analyze the relationship between pre-discharge opioid dosage and long-term opioid use.

Main Methods:

Retrospective cohort study of 376 patients undergoing MILR from March 2019 to May 2022.
Chronic opioid usage defined as use at least 30 days post-surgery.
Multivariable logistic regression analysis to identify predictive factors.

Main Results:

16.5% of patients used opioids at 30 days, decreasing to 8.5% at 90 days.
Higher morphine milligram equivalents (MMEs) on the day before discharge significantly predicted chronic opioid usage.
Each 10-unit increase in pre-discharge MMEs increased the odds of 30-day opioid use by 21%.

Conclusions:

Pre-discharge opioid dosage is a key predictor of chronic opioid use after MILR.
Further research into early outpatient interventions like nerve blocks may reduce long-term opioid reliance.