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Safe, Repeated Treatment With Electroconvulsive Therapy in Combination With KarXT

Jason M Andrus1, Sohag N Sanghani

  • 1*Northwell, New Hyde Park, NY; and †Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY.

The Journal of ECT
|June 10, 2025
PubMed
Summary

This case study reports the first known safe combination of KarXT, a novel antipsychotic, and electroconvulsive therapy (ECT). The findings suggest KarXT and ECT can be administered concurrently without adverse effects.

Keywords:
CobenfyKarXTcombination therapyelectroconvulsive therapytrospiumxanomeline

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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