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Cardiovascular burden of individuals diagnosed with idiopathic hypersomnia: Real-World Idiopathic Hypersomnia Total

Ragy Saad1, Prasheel Lillaney1, Deb A Profant1

  • 1Jazz Pharmaceuticals, 3170 Porter Drive, Palo Alto, CA, 94304, USA.

Sleep Medicine
|June 10, 2025
PubMed

Insights

Individuals with idiopathic hypersomnia face significantly higher cardiovascular risks, including heart disease and stroke. This highlights the need for careful monitoring and management of cardiovascular health in these patients.

Area of Science:

  • Cardiology
  • Neurology
  • Epidemiology

Background:

  • Idiopathic hypersomnia (IH) is a rare sleep disorder with limited research on its association with cardiovascular risk.
  • Understanding the cardiovascular implications of IH is crucial for comprehensive patient care.

Purpose of the Study:

  • To compare the prevalence of cardiovascular conditions and events in individuals diagnosed with idiopathic hypersomnia versus matched controls without the condition.
  • To quantify the increased odds of specific cardiovascular outcomes in the IH population.

Main Methods:

  • A retrospective analysis of claims data from Merative™ MarketScan® Research Databases (12/2013-2/2020) was conducted.
  • Cohorts of individuals with idiopathic hypersomnia (n=11,412) and matched controls (n=57,058) were established based on specific inclusion criteria.
  • Unconditional logistic regression was used to compare the odds of prevalent cardiovascular conditions over a 2-year period.

Main Results:

  • Individuals with idiopathic hypersomnia exhibited significantly higher odds of numerous cardiovascular conditions.
  • These included cardiovascular disease (OR 2.26), major adverse cardiovascular events (OR 2.08), stroke (OR 2.07), hypertension (OR 2.02), heart failure (OR 1.97), and myocardial infarction (OR 1.74).

Conclusions:

  • The study demonstrates a substantially elevated risk of prevalent cardiovascular conditions and events in individuals with idiopathic hypersomnia.
  • These findings underscore the importance for clinicians to consider the cardiovascular risk profile of patients when managing idiopathic hypersomnia.
Abstract

Keywords:
Cardiovascular diseasesCohort studiesHealthcare administrative claimsHypertensionIdiopathic hypersomniaRetrospective studies

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