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Updated: Jun 12, 2025

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Small fiber neuropathy
Teresa Sevilla1, Lucía Galán Dávila2
1Unidad de Enfermedades Musculares, Departamento de Neurología, Hospital Universitario y Politécnico La Fe; Grupo de Investigación de Ataxia y Enfermedades Neuromusculares IISLAFE, Valencia, España; Departamento de Medicina, Universidad de Valencia University; Centro de Investigación Neurológica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, España.
Abstract:
Small fiber neuropathy are a frequent cause of consultation in neurology. The estimated prevalence is of minimum 53 cases/100.000 inhabitants. The most frequent symptoms are neuropathic pain and dysautonomic disfunction. Symptoms, examination, neurophysologic test and skin biopsy are the pillars in its diagnosis. In the last years new causes of SFN has been described as for example mutations in sodium channel or immune causes as TS-HDS, FGFR-3 y plexina D1. Nowadays the treatment of SFN is mainly symptomatic including antidepressives and antiepileptics in a essay-mistake approach. However this new knowledge in the field may lead to a better definition of phenotype and genotype and a more personalized treatment.
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