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FDG PET/CT in Splenic Metastasis From Renal Cell Carcinoma

  • 0Department of Urology, The First Hospital of China Medical University.
Clinical Nuclear Medicine +

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June 10, 2025

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June 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Splenic metastasis from renal cell carcinoma is rare. This study details FDG PET/CT imaging findings in two rare cases of renal cell carcinoma metastasis to the spleen, noting varying levels of tumor activity.

Area Of Science

  • Oncology
  • Radiology
  • Nuclear Medicine

Background

  • Splenic metastasis from renal cell carcinoma (RCC) is uncommon, occurring in less than 1% of cases.
  • Isolated splenic metastasis from RCC is exceptionally rare.
  • Accurate diagnosis and staging are crucial for effective RCC management.

Purpose Of The Study

  • To describe the findings of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in patients with splenic metastasis from renal cell carcinoma.
  • To highlight the utility of FDG PET/CT in evaluating rare instances of RCC spread to the spleen.

Main Methods

  • Case series describing two patients with histologically confirmed splenic metastasis from RCC.
  • Utilized FDG PET/CT imaging to assess metabolic activity of splenic lesions.
  • Correlated imaging findings with histological subtypes of RCC.

Main Results

  • FDG PET/CT demonstrated mild tracer uptake in a solitary splenic metastasis from clear cell RCC.
  • Intense FDG uptake was observed in a splenic metastasis associated with renal collecting duct carcinoma, alongside multiple extrasplenic metastases.
  • Imaging characteristics varied based on the histological subtype of the primary renal tumor.

Conclusions

  • FDG PET/CT can visualize splenic metastases from RCC.
  • The metabolic activity of splenic metastases on FDG PET/CT may differ based on the RCC subtype.
  • FDG PET/CT is a valuable tool for detecting and characterizing rare splenic metastases in RCC patients.

Keywords:

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