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[DICER1-mutant primary intracranial sarcoma: analysis of five cases]

Z J Duan1, J Feng1, J P Zhang1

  • 1Department of Pathology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|June 10, 2025
PubMed
Summary

DICER1-mutant primary intracranial sarcoma, a new tumor entity, typically presents as high-grade spindle cells in young patients. Diagnosis relies on genetic alterations in DICER1 and specific morphological features.

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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...