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Experimental pancreatic islet transplantation
Transplantation of isolated islets of Langerhans has been suggested as a treatment of certain forms of diabetes mellitus. Injection of 200-400 syngeneic pancreatic islets isolated by collagenase digestion into the pancreas or submandibular gland of diabetic rats rendered most of the hosts nearly normoglycaemic. Blood glucose determinations were monitored for 2 months after islet transplantation. Although intrapancreatic and intrasubmandibular implantation reduced hyperglycaemia and polyuria in these animals, consistent normal values were rarely achieved.
Transplantation of isolated islets of Langerhans has been suggested as a treatment of certain forms of diabetes mellitus. Injection of 200-400 syngeneic pancreatic islets isolated by collagenase digestion into the pancreas or submandibular gland of diabetic rats rendered most of the hosts nearly normoglycaemic. Blood glucose determinations were monitored for 2 months after islet transplantation. Although intrapancreatic and intrasubmandibular implantation reduced hyperglycaemia and polyuria in these animals, consistent normal values were rarely achieved.