Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

4.3K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved segmentation accuracy in high-resolution peripheral quantitative computed tomography scans of carpal bones using adaptive local thresholding.

JBMR plus·2026
Same author

Sex differences in the power-duration relationship for dynamic knee extension are largely explained by muscle size.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Effects of contrast on opportunistic computed tomography vertebral bone mineral density analysis using internal calibration.

JBMR plus·2026
Same author

Finite Element Analysis for the Load-Bearing Femur and Tibia in the Human Knee Using an in vivo HR-pQCT Protocol.

Journal of biomechanical engineering·2026
Same author

Open and reproducible research in musculoskeletal imaging: why it matters and how to implement it with the guidelines of the Open and Reproducible Musculoskeletal Imaging Research (ORMIR) community.

JBMR plus·2026
Same author

Early skeletal deteriorations following short-duration spaceflight.

NPJ microgravity·2026
Same journal

Author response to the letter to the editor regarding "Hip Response to Romosozumab in Glucocorticoid Users: Beyond Systemic Bone Turnover Markers".

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Revisiting the Osteoporosis Self-Assessment Tool (OST): evidence from a multi-cohort study in Asia supporting age-dependent thresholds.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Parkinson's disease severity and treatment classification in interpreting bisphosphonate-associated fracture risk.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Hip response to romosozumab in glucocorticoid users: beyond systemic bone turnover markers.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2025

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.1K

Quantifying localized bone loss in clinical computed tomography using void spaces.

Annabel R Bugbird1,2, Bryn E Matheson1,2, Matthias Walle1

  • 1McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|June 10, 2025
PubMed
Summary
This summary is machine-generated.

This study validated quantitative computed tomography (QCT) for assessing localized bone loss, known as void spaces, which standard CT misses. Void spaces were found to be region-specific, not systemic, offering new insights into bone fragility.

Keywords:
Bone lossHigh-resolution peripheral quantitative computed tomographyOsteoporosisQuantitative computed tomographyVoid space

More Related Videos

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
09:36

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

9.3K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

1.8K

Related Experiment Videos

Last Updated: Jun 12, 2025

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.1K
Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
09:36

Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin

Published on: March 14, 2018

9.3K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

1.8K

Area of Science:

  • Orthopedics and Bone Biology
  • Medical Imaging and Diagnostics

Background:

  • Localized trabecular bone loss (void spaces) is linked to bone fragility but is typically measured with high-resolution peripheral quantitative computed tomography (HR-pQCT), which is limited to peripheral sites.
  • It remains unknown if these void spaces occur at axial skeletal sites, necessitating further investigation.

Purpose of the Study:

  • To validate the use of quantitative computed tomography (QCT) for assessing void spaces in the hip and spine.
  • To determine the systemic prevalence of void spaces by combining QCT and HR-pQCT measures.

Main Methods:

  • Adapted HR-pQCT methodology for QCT to assess void spaces (volume and ratio) in 101 participants, comparing results between modalities.
  • Measured void spaces in a separate cohort of 209 participants using HR-pQCT (radius, tibia) and QCT (lumbar spine, hip).
  • Assessed relationships between void space measures across skeletal sites using Pearson's correlation.

Main Results:

  • QCT validation against HR-pQCT showed strong correlations for void space volume (r=0.88) and ratio (r=0.83) at the knee.
  • Void space ratio correlations were highest between similar skeletal sites (e.g., lumbar spine levels) and weaker between dissimilar sites (e.g., radius and spine).

Conclusions:

  • Quantitative computed tomography (QCT) is validated for identifying skeletal void spaces, previously measurable only with HR-pQCT.
  • Void spaces are localized to specific skeletal regions rather than being systemic.
  • Tracking void spaces provides insights into bone fragility and may guide future orthopedic treatments.