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Updated: Jun 14, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
How sustainable are hypocaloric and balanced diets for weight loss?
Ramona De Amicis1,2, Andrea Foppiani3,4, Alessandro Leone3,4
1International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Celoria, 2, 20133, Milan, Italy. ramona.deamicis@unimi.it.
Background:
Promoting healthy diets with low environmental impact is pivotal. The EAT-IT diet aligns with the EAT-Lancet Commission, tailored to Italian food habits. However, a comparison with weight loss diets has not been done. This cross-sectional study compares EAT-IT with historical diets of an urban nutritional care facility.
Objective:
To compare conventional hypocaloric and balanced weight-loss diets with the sustainable EAT-IT diet, investigating their alignment, the influence of BMI and sex on EAT-IT adherence, to optimize the EAT-IT diet for weight management.
Methods:
4032 patients (72% female, median age 49y, BMI 29 kg/m2) received hypocaloric diets based on Mediterranean principles (51% carbohydrates, 31% lipids, 0.9 g/kg body weight protein, 17 g/1000 kcal fiber), following Italian dietary guidelines.
Results:
Linear regression revealed lower EAT-IT alignment in males (-2.6%, p < 0.001) and a small BMI effect on food group adherence (0.4%, p = 0.005). Only 44% of prescribed food groups were in line to EAT-IT. Protein sources (fish 13%, red meat 13%) were generally higher than EAT-IT, except for legumes (26%) and nuts (10%) prescribed in lower quantities and frequencies, as well as vegetable oil (12%) and fresh fruits (11%). Complex carbohydrates-rich foods (13% bread, 12% pasta/cereals) and vegetables (21%) were prescribed in higher quantities in hypocaloric diets, being more aligned with the EAT-IT pattern.
Conclusions:
Protein sources, being less sustainable, pose challenges in hypocaloric diets. Differences in consumption of vegetable foods were found according to sex and BMI, highlighting the struggle to meet EAT-IT sustainability criteria. Reconciliation between sustainable and hypocaloric dietary interventions is crucial.
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