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Related Experiment Video

Updated: Jun 12, 2025

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The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children's

Ekene A Onwuka1, Christina L Magyar2, Bailey A Martin-Giacalone3

  • 1Department of Pediatric Surgery, Surgical Oncology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.

HGG Advances
|June 11, 2025
PubMed
Summary
This summary is machine-generated.

Genetic ancestry impacts childhood rhabdomyosarcoma (RMS) survival. Children with South Asian or Asian-Pacific Islander ancestry had worse outcomes in specific RMS subtypes compared to European ancestry. This highlights the need for ancestry-informed precision medicine.

Keywords:
South Asian/Asian-Pacific Islandergenetic ancestryhealth disparitiesrhabdomyosarcomasurvival outcomes

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Area of Science:

  • Pediatric Oncology
  • Genetics
  • Cancer Epidemiology

Background:

  • Genetic ancestry's role in childhood cancer outcomes is emerging.
  • The impact of genetic ancestry on pediatric rhabdomyosarcoma (RMS) survival remains unknown.

Purpose of the Study:

  • To investigate the association between genetic ancestry and survival in children diagnosed with rhabdomyosarcoma.
  • To explore if genetic ancestry influences outcomes in specific RMS subtypes and fusion statuses.

Main Methods:

  • Secondary analysis of biobanking, genomic, and clinical data from 920 pediatric RMS patients (2005-2017).
  • Genetic ancestry estimation using Grafpop software.
  • Cox regression analysis to assess the association between genetic ancestry and event-free survival (EFS) and overall survival (OS), adjusting for covariates.

Main Results:

  • In embryonal RMS and fusion-negative RMS, South Asian or Asian-Pacific Islander ancestry was linked to significantly worse EFS and OS compared to European ancestry.
  • Hazard ratios for worse outcomes ranged from 2.01 to 2.33 (p < 0.03) for these ancestry groups in specific RMS subtypes.

Conclusions:

  • Genetic ancestry is a significant factor influencing survival outcomes in pediatric rhabdomyosarcoma, particularly within specific subtypes.
  • Further research into genetic ancestry's impact can enhance precision medicine strategies for pediatric cancer patients.