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The histologic results in multiple-type HPV infections.

Sevgi Koç1, Dilek Yüksel1, Eylem Ünlübilgin2

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Multiple human papillomavirus (HPV) infections are less common in high-grade squamous intraepithelial lesions (HSIL) and cervical cancer. However, multiple HPV types are notable in older patients with HSIL and cervical cancer.

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Area of Science:

  • Gynecology
  • Oncology
  • Virology

Background:

  • Human papillomavirus (HPV) is a major cause of cervical cancer.
  • Understanding the prevalence and impact of multiple HPV infections is crucial for cervical cancer screening and management.

Purpose of the Study:

  • To determine the incidence of multiple-type HPV infections in women referred for colposcopy.
  • To compare the association of multiple-type versus single-type HPV infections with high-grade squamous intraepithelial lesions (HSIL) and cervical cancer.

Main Methods:

  • Retrospective analysis of cytological and histopathological data from 2070 HPV-positive women.
  • Categorization of patients into single-type and multiple-type HPV infection groups.
  • Age-stratified comparison of HSIL and cervical cancer rates.

Main Results:

  • Multiple-type HPV infections were present in 24.9% of the study population.
  • Multiple-type HPV infection rates varied across different cytological findings, with the highest in LSIL (31.4%) and lowest in cancer (12.5%).
  • Age-stratified analysis showed varied multiple-type HPV infection rates, with 27.8% in women under 30 and 27.3% in those 50 and older.

Conclusions:

  • Multiple-type HPV infections are less frequent in HSIL and cervical cancer compared to single-type infections.
  • Despite being less common overall, multiple-type HPV infections were observed more frequently in older women diagnosed with HSIL and cervical cancer.