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Updated: May 4, 2026
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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
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The histologic results in multiple-type HPV infections.
Sevgi Koç1, Dilek Yüksel1, Eylem Ünlübilgin2
1Clinic of Gynecologic Oncology, University of Health Sciences Türkiye, Etlik Zübeyde Hanım Women's Health Education and Research Hospital, Ankara, Türkiye.
Journal of the Turkish German Gynecological Association
|June 11, 2025
Summary
Multiple human papillomavirus (HPV) infections are less common in high-grade squamous intraepithelial lesions (HSIL) and cervical cancer. However, multiple HPV types are notable in older patients with HSIL and cervical cancer.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Human papillomavirus (HPV) is a major cause of cervical cancer.
- Understanding the prevalence and impact of multiple HPV infections is crucial for cervical cancer screening and management.
Purpose of the Study:
- To determine the incidence of multiple-type HPV infections in women referred for colposcopy.
- To compare the association of multiple-type versus single-type HPV infections with high-grade squamous intraepithelial lesions (HSIL) and cervical cancer.
Main Methods:
- Retrospective analysis of cytological and histopathological data from 2070 HPV-positive women.
- Categorization of patients into single-type and multiple-type HPV infection groups.
- Age-stratified comparison of HSIL and cervical cancer rates.
Main Results:
- Multiple-type HPV infections were present in 24.9% of the study population.
- Multiple-type HPV infection rates varied across different cytological findings, with the highest in LSIL (31.4%) and lowest in cancer (12.5%).
- Age-stratified analysis showed varied multiple-type HPV infection rates, with 27.8% in women under 30 and 27.3% in those 50 and older.
Conclusions:
- Multiple-type HPV infections are less frequent in HSIL and cervical cancer compared to single-type infections.
- Despite being less common overall, multiple-type HPV infections were observed more frequently in older women diagnosed with HSIL and cervical cancer.
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