Electrochemical Cross-Dehydrogenative Coupling of P(O)-H/P-H Bonds with Heteroatom Nucleophiles: Access to P(O)-N and
Sifeng Li1,2, Xingchen Li1,3, Dilnigar Askar1,4
1School of Food and Drug/Institute of Marine Biomedicine, Shenzhen Polytechnic University, Shenzhen 518055, China.
Abstract:
A unified electrochemical cross-dehydrogenative coupling (CDC) of heteroatom nucleophiles with H-phosphine oxides, H-phosphinates, H-phosphites, and in situ-formed H-phosphine sulfides has been developed for the synthesis of N-aryl phosphamides, phosphoramidates, thiophosphamides, phosphinodithioates, and phosphinothioates. This electrochemical reaction exhibited good function tolerance and high atomic economy under metal-, light-, base-, and oxidant-free conditions with releasing molecular hydrogen as the sole and nontoxic byproduct.
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