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Related Experiment Video

Updated: Jun 13, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Advanced lung cancer inflammation index and its predictive value for all-cause and cardiovascular mortality among

Guiyou Wu^1,2, Dongqiang Gu^1,2, Haigang Jia^1,2

¹Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Frontiers in Medicine

|June 11, 2025

Summary

Higher Advanced Lung Cancer Inflammation Index (ALI) scores are linked to lower mortality in osteoarthritis (OA) patients. This index effectively predicts survival, offering clinical value for risk assessment in OA populations.

Keywords:

NHANES advanced lung cancer inflammation index all-cause mortality cardiovascular mortality osteoarthritis

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Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

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Published on: March 21, 2021

Area of Science:

Biomedical Science
Epidemiology
Clinical Research

Background:

Osteoarthritis (OA) prevalence is rising globally, with inflammation and nutritional status influencing disease severity.
The Advanced Lung Cancer Inflammation Index (ALI) integrates inflammation markers and nutritional status.
Understanding ALI's impact on mortality in OA patients is crucial.

Purpose of the Study:

To investigate the association between the Advanced Lung Cancer Inflammation Index (ALI) and all-cause and cardiovascular disease (CVD) mortality in individuals with osteoarthritis (OA).
To explore the potential non-linear relationship and threshold effects of ALI on mortality outcomes in the OA population.

Main Methods:

Utilized data from the National Health and Nutrition Examination Survey (NHANES) database (2001-2018).
Employed weighted Kaplan-Meier methods, multivariate-adjusted Cox regression, and restricted cubic spline (RCS) analyses.
Conducted stratified analyses and interaction tests to assess subgroup effects and robustness of findings.

Main Results:

Higher ALI scores were significantly associated with reduced all-cause and CVD mortality in OA patients.
A non-linear, L-shaped relationship was observed, with a protective effect of ALI above a threshold of 61.18.
Subgroup analysis indicated a stronger association between ALI and all-cause mortality in female OA patients.

Conclusions:

The Advanced Lung Cancer Inflammation Index (ALI) demonstrates significant effectiveness in predicting mortality outcomes for patients with osteoarthritis (OA).
ALI serves as a valuable tool for clinical risk assessment and prognosis in the OA population.
The findings highlight the clinical utility of ALI in managing OA patients.