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Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report

Jasmine H Wong1, Udele Tagoe2, Hatice B Zengin1,3

  • 1Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Gynecologic Oncology Reports
|June 11, 2025
PubMed

Pemphigoid gestationis (PG) is well described in pregnancy, classically presenting as a pruritic, periumbilical rash in multiparous women in the second or third trimester. We describe a unique case of a woman with gestational trophoblastic neoplasia (GTN) status post dilation and curettage on methotrexate (MTX) who presented with a diffuse, pruritic rash. After the rash persisted and flared despite multiple cycles of MTX, biopsies were obtained supporting a diagnosis of PG. It is important to consider PG on the differential in non-pregnant patients with GTN with a persistent pruritic rash, even in the setting of ongoing treatment with MTX.

Keywords:
Gestational trophoblastic neoplasiaMethotrexatePemphigoid gestationis

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