High body mass index increases the risk for prostate cancer and high Gleason score in northern Tanzania: data from prostate cancer screening
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View abstract on PubMed
Summary
This summary is machine-generated.Higher body mass index (BMI) significantly increases prostate cancer (Pca) risk in Tanzanian men. Maintaining a normal BMI may help reduce the likelihood of developing Pca, particularly aggressive forms.
Area Of Science
- Oncology
- Epidemiology
- Public Health
Background
- Prostate cancer (Pca) is prevalent in Tanzania, yet data on body mass index (BMI) and Pca risk is limited.
- The association between BMI and Pca is controversial globally.
- This study addresses the data gap regarding BMI's role in Pca risk among African men in Tanzania.
Purpose Of The Study
- To investigate the association between BMI and Pca risk in Tanzanian men.
- To determine if BMI influences the likelihood of developing Pca.
- To explore the relationship between BMI and Pca aggressiveness, indicated by Gleason scores.
Main Methods
- Analysis included 572 Tanzanian men aged ≥40 years with elevated prostate-specific antigen (>4 ng/mL).
- Participants were categorized into BMI groups: underweight (<18.5 kg/m²), normal (18.5-24.9 kg/m²), overweight (25.0-29.9 kg/m²), and obese (≥30 kg/m²).
- Logistic regression was employed to calculate odds ratios for Pca and high Gleason score (≥4+3) across BMI categories.
Main Results
- Overweight and obese men showed significantly higher odds of Pca diagnosis compared to normal-weight men (OR 6.95 and 23.65, respectively).
- Obesity was strongly associated with an increased risk of Pca (OR 23.65, 95% CI; 11.45-48.87).
- Obese men also had significantly higher odds of high Gleason score Pca (OR 3.63, 95% CI; 1.52-8.70).
Conclusions
- Elevated BMI in Tanzanian men with high prostate-specific antigen is linked to a significant risk of Pca, often with high Gleason scores.
- Maintaining a normal BMI is recommended for potentially reducing Pca development risk.
- Findings highlight the importance of BMI management in Pca prevention strategies for this population.
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