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Finerenone and semaglutide: Role in heart failure with reduced ejection fraction

Muhammad Abdul Rehman Gulzar1

  • 1Multan Medical and Dental College, Multan 60000, Punjab, Pakistan. abdulrehman8104@gmail.com.

World Journal of Cardiology
|June 11, 2025
PubMed

Insights

Finerenone and semaglutide show potential in managing heart failure with preserved ejection fraction (HFpEF) in patients with obesity and type 2 diabetes. Further research is needed to understand their mechanisms and optimize cardiorenal protection.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Obesity and type 2 diabetes mellitus frequently coexist with heart failure (HF), potentially driving HF with preserved ejection fraction (HFpEF).
  • Aldosterone antagonists offer cardiorenal protection in chronic kidney disease but are limited by side effects.
  • The mechanisms of action for finerenone and semaglutide in HFpEF remain unclear despite therapeutic advancements.

Keywords:
AntifibroticFinerenoneGlucagon-like peptide 1Heart failureMineralocorticoid receptor antagonistPolypill frameworkSemaglutide

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