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Ppm level palladium catalyzed regioselective remote arylation of alkenyl alcohols
Chong Liu1, Ling Wang2, Haibo Ge1
1Department of Chemistry and Biochemistry, Texas Tech University Lubbock Texas 79409 USA Haibo.Ge@ttu.edu.
Abstract:
Recent studies highlight the importance and application of parts per million (ppm) palladium concentration in catalytic reactions. Lowering catalyst loading minimizes costs, simplifies purification, and reduces metal contamination, making it highly attractive for pharmaceutical and fine chemical manufacturing. Here, we report a ppm level Pd-catalyzed remote arylation reaction of alkenols, achieving high efficiency, regioselectivity, and flexible carbonyl scaffold construction. Notably, this strategy exhibits excellent compatibility with styrene-derived substrates and has been successfully achieved on a gram scale, providing a solid foundation for potential large-scale applications.
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