Related Experiment Video
Updated: Jun 13, 2025
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
GNG7 as a tumor-suppressor gene in lung adenocarcinoma: implications for prognosis and immune-based therapies
Kexin Luo1,2,3,4, Meihan Liu1,3,4,5, Zhongqin Peng1,2,4
1Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Introduction:
Lung adenocarcinoma (LUAD) is among the most prevalent and lethal forms of cancer worldwide, largely due to the lack of early symptoms and frequent late-stage diagnosis. G protein γ subunit 7 (GNG7) has been implicated in the regulation of cell proliferation, apoptosis, and migration across various cancers. However, its immunological role in LUAD progression remains poorly understood.
Methods:
We analyzed The Cancer Genome Atlas (TCGA) database to assess the relationship between GNG7 expression and clinical outcomes in LUAD. Immune cell infiltration and immune-related gene expression were evaluated in association with GNG7 levels. In vitro functional assays, including proliferation, migration, invasion, and apoptosis assays, were performed following GNG7 overexpression. A prognostic model was constructed based on immune-related genes regulated by GNG7 and validated using the GSE31210 and IMvigor210 cohorts.
Results:
Low GNG7 expression was associated with enhanced tumor growth and poor prognosis in LUAD patients. GNG7 expression correlated significantly with immune cell infiltration and key immune regulatory markers. In vitro, GNG7 overexpression suppressed LUAD cell proliferation, migration, and invasion, while promoting apoptosis. The developed GNG7-related immune gene prognostic model effectively predicted both patient prognosis and immunotherapy response.
Discussion:
Our findings highlight the critical role of GNG7 in LUAD progression and its modulation of the tumor immune microenvironment. GNG7 shows promise as a prognostic biomarker and potential therapeutic target for immune-based LUAD treatment strategies.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:39lncRNA - Long Non-coding RNAs
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
02:23Abnormal Proliferation
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...