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Updated: Jun 13, 2025

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
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Low Arterial Stiffness by Pulse Wave Analysis and Aortic Diseases

Akira Sakamoto1, Yutaka Nakamura1, Nobuyuki Kagiyama1

  • 1Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine Tokyo Japan.

Circulation Reports
|June 11, 2025
PubMed

Insights

Low cardio-ankle vascular index (CAVI) does not appear to increase the risk of aortic diseases like dissection or aneurysm, nor Marfan syndrome. Further research is needed to understand the clinical significance of low arterial stiffness markers.

Area of Science:

  • Cardiovascular research
  • Vascular health
  • Arterial stiffness assessment

Background:

  • Cardio-ankle vascular index (CAVI) measures arterial stiffness, offering blood pressure-independent vascular function assessment.
  • The clinical implications of low CAVI values are not well-understood.
  • Connective tissue diseases can affect arterial walls, potentially leading to aortic diseases and low CAVI.

Purpose of the Study:

  • To investigate the association between low CAVI and connective tissue diseases.
  • To determine if low CAVI predicts subsequent aortic diseases (dissection/aneurysm) or Marfan syndrome.

Main Methods:

  • Retrospective observational study at a single center.
  • Included 17,364 patients aged 20-80 years undergoing CAVI analysis.
  • Low CAVI defined as the lowest 2.5 percentile within sex- and age-specific groups.

Main Results:

  • No significant difference in the prevalence of aortic diseases between low CAVI and normal CAVI groups (3.99% vs. 3.99%).
  • Similar prevalence of Marfan syndrome in both groups (0.04% vs. 0.07%).
  • P-values indicated no statistical significance (P>0.99 for both comparisons).

Conclusions:

  • This study found no evidence linking low CAVI to an increased prevalence of aortic dissection, aneurysm, or Marfan syndrome.
  • The clinical significance of low CAVI in vascular diseases requires further investigation.
Abstract

Keywords:
Aortic aneurysmAortic dissectionArterial stiffness analysisCAVIMarfan syndrome

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