Stem cell therapy for urethra and ureter tissue engineering: A systematic literature review on animal studies
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View abstract on PubMed
Summary
This summary is machine-generated.Adipose-derived stem cells are most effective for ureter and urethra tissue engineering. Further research is needed to explore other stem cell types for ureter regeneration.
Area Of Science
- Regenerative Medicine
- Biomaterials Science
- Urology
Background
- Tissue engineering aims to restore or replace damaged tissues.
- Ureter and urethra reconstruction presents significant clinical challenges.
- Stem cells offer promising therapeutic potential for urogenital tissue regeneration.
Purpose Of The Study
- To systematically review and identify optimal stem cells for ureter and urethra tissue engineering.
- To evaluate the efficacy of different stem cell types and scaffolds in animal models.
- To summarize current advancements and limitations in the field.
Main Methods
- Systematic literature review of Scopus, PubMed, and Embase databases up to December 2024.
- Inclusion of 26 original studies on ureter and urethra tissue regeneration in animal models.
- Analysis of stem cell types, scaffold materials, and regenerative outcomes.
Main Results
- Adipose-derived stem cells were most frequently used (14 studies) for both ureter and urethra regeneration.
- Bone marrow-derived stem cells showed potential for collagen and vessel formation.
- Various synthetic and non-synthetic scaffolds were employed, with synthetic materials used more frequently.
- Limited data exists for ureter tissue engineering, though adipose-derived stem cells showed promise.
Conclusions
- Adipose-derived stem cells are currently the most studied and effective for ureter and urethra tissue engineering.
- Bone marrow-derived and urine-derived stem cells also demonstrate regenerative capabilities for urothelium and smooth muscle.
- Further investigation into diverse stem cell sources and optimized conditions is crucial for advancing ureter tissue engineering.
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