Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.0K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.0K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current trends in machine learning for surface-enhanced Raman spectroscopy.

The Analyst·2026
Same author

Betel leaf-mediated zinc oxide nanoparticle-coated silk fibres: a sustainable approach for biomedical applications.

RSC advances·2025
Same author

Hydrogen Sulfide-Induced Activatable Photodynamic Therapy Adjunct to Disruption of Subcellular Glycolysis in Cancer Cells by a Fluorescence-SERS Bimodal Iridium Metal-Organic Hybrid.

ACS applied materials & interfaces·2024
Same author

HER2 siRNA Facilitated Gene Silencing Coupled with Doxorubicin Delivery: A Dual Responsive Nanoplatform Abrogates Breast Cancer.

ACS applied materials & interfaces·2024
Same author

NADH-depletion triggered energy shutting with cyclometalated iridium (III) complex enabled bimodal Luminescence-SERS sensing and photodynamic therapy.

Biosensors & bioelectronics·2022
Same author

IndiFluors: A New Full-Visible Color-Tunable Donor-Acceptor-Donor (D<sub>1</sub>-A-D<sub>2</sub>) Fluorophore Family for Ratiometric pH Imaging during Mitophagy.

ACS sensors·2022

Related Experiment Video

Updated: Jun 12, 2025

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

49.5K

Microscopic menace: exploring the link between microplastics and cancer pathogenesis.

Manu M Joseph1, Jyothi B Nair2, Anu Mary Joseph3

  • 1Department of Life Sciences, CHRIST University, Bengaluru, Karnataka, 560029, India. manu.joseph@christuniversity.in.

Environmental Science. Processes & Impacts
|June 11, 2025
PubMed
Summary

Microplastics are tiny plastic particles found everywhere, posing potential risks to human health, especially cancer development. Further research is crucial to understand and address this growing environmental and health concern.

More Related Videos

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.2K
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
06:46

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish

Published on: July 4, 2021

4.7K

Related Experiment Videos

Last Updated: Jun 12, 2025

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

49.5K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.2K
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
06:46

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish

Published on: July 4, 2021

4.7K

Area of Science:

  • Environmental Science
  • Toxicology
  • Oncology

Background:

  • Microplastics, defined as plastic particles (1 μm–5 mm), are emerging contaminants with widespread environmental presence.
  • Their bioaccumulation and persistence across ecosystems raise concerns about potential human health impacts.
  • Cancer remains a leading cause of mortality, necessitating investigation into novel contributing factors.

Purpose of the Study:

  • To review the classification, environmental persistence, and bioaccumulation of microplastics.
  • To explore the potential link between microplastic exposure and cancer pathogenesis.
  • To highlight the need for improved detection methods and clinical research.

Main Methods:

  • Literature review of epidemiological and experimental studies.
  • Analysis of existing data on microplastic detection and characterization.
  • Discussion of current knowledge gaps and future research directions.

Main Results:

  • Microplastics are pervasive environmental contaminants with demonstrated bioaccumulation.
  • Evidence suggests a potential connection between microplastics and cancer development, though further research is needed.
  • Current methods for detecting microplastics in biological samples require improvement.

Conclusions:

  • Understanding the full impact of microplastics on human health, particularly cancer, requires significant further investigation.
  • Standardized research protocols, regulatory measures, and interdisciplinary collaboration are essential.
  • Addressing the threat of microplastics in cancer pathogenesis demands a concerted, multi-domain scientific effort.