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Updated: Jun 12, 2025
Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
The Unusual Actinotigum schaalii (Formerly Named Actinobaculum schaalii) Bacteremia
Background:
This study aimed to evaluate unusual case reports about Actinotigum schaalii (A. schaalii) bacteremia patients in the past 20 years.
Methods:
A retrospective review of A. schaalii bacteremia patients collected from MEDLINE between January 2005 and November 2024.
Results:
Of 34 cases, the identification (ID) of A. schaalii for clinical samples included blood (n = 34), urine (n = 6), valve (n = 1), and biopsy (n = 1). Polymicrobial infections were 32.4% (n = 11 out of 34) in this study. Antimicrobial susceptibility tests (ASTs) were performed in most cases. The A. schaalii isolates were sensitive to penicillin, β-lactam combination agent, lincosamide, tetracycline, nitrofuran, cephem, carbapenem, oxazolidinone, ansamycin, macrolide, and glycylcycline; but resistant to fluoroquinolone, nitroimidazole, aminoglycoside, and folate pathway antagonists.
Conclusions:
Microbiologists should perform the correct ID and suitable AST of the potentially invasive A. schaalii to help clinicians obtain the appropriate antimicrobial coverage for serious systemic infections.
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