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Updated: May 7, 2026

Echocardiographic Assessment of the Right Heart in Mice

Echocardiographic Assessment of the Right Heart in Mice

Published on: November 27, 2013

Image-based computational hemodynamics in the right heart.

Francesca Renzi^1,2, Giovanni Puppini³, Giovanni B Luciani⁴

¹Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Piazzale Ludovico Scuro 10, 37134, Verona, VR, Italy. francesca.renzi@univr.it.

Biomechanics and Modeling in Mechanobiology

|June 11, 2025

Summary

This summary is machine-generated.

This study introduces patient-specific right heart simulations, integrating tricuspid valve dynamics for improved accuracy. These models enhance understanding of blood flow in healthy and diseased states, aiding diagnosis.

Keywords:

Computational fluid dynamics In silico simulations Patient-specific analysis Pulmonary regurgitation Right heart Tetralogy of Fallot

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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Echocardiographic Assessment of the Right Heart in Mice

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Published on: November 27, 2013

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Area of Science:

Cardiovascular Physiology
Medical Imaging
Computational Fluid Dynamics

Background:

Right heart (RH) function is crucial for diagnosing acquired and congenital heart diseases.
Characterizing RH hemodynamics is complex due to intricate geometries.
Impaired RH function is prevalent in various cardiac conditions.

Purpose of the Study:

To develop a patient-specific computational modeling pipeline for right heart hemodynamics.
To integrate patient-specific tricuspid valve dynamics into RH models for enhanced accuracy.
To analyze blood flow in healthy, repaired Tetralogy of Fallot (ToF) right hearts, and post-pulmonary valve replacement.

Main Methods:

Reconstruction of patient-specific RH geometry and motion from cine MRI.
Development of a novel procedure integrating tricuspid valve dynamics.
Application of large eddy simulation sigma model for turbulent flow analysis.

Main Results:

The pipeline successfully simulated RH hemodynamics in various conditions.
Integration of tricuspid valve dynamics improved blood flow simulation accuracy.
Analysis revealed insights into vena cava inflow, atrial function impact, and turbulent energy dissipation.

Conclusions:

Patient-specific RH simulations offer valuable diagnostic insights.
Accurate modeling of the entire RH, including valves, is essential for understanding cardiac function.
This approach advances the study of RH blood flow in health and disease.