Related Experiment Video
Updated: Aug 1, 2026

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
Published on: November 30, 2022
Enhancing generalization in zero-shot multi-label endoscopic instrument classification
Raphaela Maerkl1, Tobias Rueckert2,3, David Rauber2
1Regensburg Medical Image Computing (ReMIC), OTH Regensburg, 93053, Regensburg, Germany. raphaela.maerkl@st.oth-regensburg.de.
Purpose:
Recognizing previously unseen classes with neural networks is a significant challenge due to their limited generalization capabilities. This issue is particularly critical in safety-critical domains such as medical applications, where accurate classification is essential for reliability and patient safety. Zero-shot learning methods address this challenge by utilizing additional semantic data, with their performance relying heavily on the quality of the generated embeddings.
Methods:
This work investigates the use of full descriptive sentences, generated by a Sentence-BERT model, as class representations, compared to simpler category-based word embeddings derived from a BERT model. Additionally, the impact of z-score normalization as a post-processing step on these embeddings is explored. The proposed approach is evaluated on a multi-label generalized zero-shot learning task, focusing on the recognition of surgical instruments in endoscopic images from minimally invasive cholecystectomies.
Results:
The results demonstrate that combining sentence embeddings and z-score normalization significantly improves model performance. For unseen classes, the AUROC improves from 43.9 % to 64.9 %, and the multi-label accuracy from 26.1 % to 79.5 %. Overall performance measured across both seen and unseen classes improves from 49.3 % to 64.9 % in AUROC and from 37.3 % to 65.1 % in multi-label accuracy, highlighting the effectiveness of our approach.
Conclusion:
These findings demonstrate that sentence embeddings and z-score normalization can substantially enhance the generalization performance of zero-shot learning models. However, as the study is based on a single dataset, future work should validate the method across diverse datasets and application domains to establish its robustness and broader applicability.
Related Concept Videos
Confocal Fluorescence Microscopy
Mass Spectrum: Interpretation
Mass Analyzers: Overview
Mass Analyzers: Common Types
Tandem Mass Spectrometry

