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Updated: Jun 12, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Pro- and Anti-Inflammatory Role of Complement in Cancer
Pradipta Pal1,2, Praneet Wahi1,2, Arvind Sahu1,2,3
1BRIC-National Centre for Cell Science (NCCS), Pune, Maharashtra, India.
None:
The complement system bridges innate and adaptive immunity, and its role in the tumor microenvironment (TME) is complex and context-dependent. Multiple recent studies have demonstrated the complement system's pro- and anti-tumor effects. In the present review, we discuss the role of complement in shaping the functions of various immune cells, including T cells, macrophages, natural killer (NK) cells, neutrophils, and dendritic cells within the TME. We also highlighted how complement proteins drive the pro- or anti-inflammatory immune responses, the associated cellular and molecular mechanisms, their influence on anti-tumor immunity, and some clinical trials targeting complement systems. A comprehensive and critical understanding of the complement system in oncoimmunology may aid in designing effective tumor-specific therapeutic strategies.
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