Drug-loaded composite materials based on polysaccharide carriers for alleviating myocardial cell damage

Heart failure, a leading cause of mortality among cardiovascular disease patients, is primarily a consequence of chronic heart failure (CHF) and myocardial tissue damage associated with apoptosis. Leveraging the pharmacological success of Dapagliflozin, an SGLT-2 inhibitor known for reducing glucose reabsorption and its preventative efficacy against cardiovascular diseases, we have engineered and synthesized a novel derivative, compound 2, to enhance therapeutic outcomes. Furthermore, we utilized chitosan (CS) as a carrier matrix and integrated a bioactive compound, compound 1, synthesized from actinomycetes, to develop an antimicrobial drug delivery material, CS-1, designated for the administration of compound 2 (CS-1@2), which exhibits pH-responsive antimicrobial effects. The physicochemical properties, in vitro biological characteristics, and bioactivity of CS-1@2 were rigorously evaluated. Results indicated that CS-1 possesses a porous structure, facilitating accelerated release of compound 2 in mildly acidic conditions. In vitro cellular assays were conducted, establishing a CHF model using doxorubicin-induced AC16 cardiomyocytes. This study aims to elucidate the mechanisms through which CS-1@2 mitigates doxorubicin-induced damage in AC16 myocardial cells, highlighting its potential in CHF management. This study lays a promising foundation for targeted therapy of chronic heart failure (CHF) and promotes its translational application in personalized cardiovascular medicine.