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Updated: Jun 13, 2025

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Telehealth Geriatric Assessment and Supportive Care Intervention (GAIN-S) Program: A Randomized Clinical Trial.

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Telehealth geriatric assessment improved physical function, mood, and quality of life in older Brazilian cancer patients. This Geriatric Assessment-Guided Intervention (GAIN-S) is effective in resource-limited settings.

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Area of Science:

  • Geriatric oncology
  • Telehealth interventions
  • Cancer care delivery

Background:

  • Older adults with cancer face access barriers to high-quality care, particularly in resource-limited settings.
  • The Geriatric Assessment-Guided Intervention (GAIN-S) was adapted for telehealth delivery to address these challenges.
  • This study evaluated GAIN-S in older Brazilians with metastatic cancer.

Purpose of the Study:

  • To assess the impact of a telehealth-adapted Geriatric Assessment-Guided Intervention (GAIN-S) on older adults with metastatic cancer.
  • To evaluate improvements in physical function, mood, quality of life, and prognostic understanding.
  • To determine the efficacy of GAIN-S in a resource-limited setting.

Main Methods:

  • A randomized clinical trial enrolled 80 adults aged ≥65 years with metastatic cancer.
  • Patients were assigned to either usual care or GAIN-S, which involved a multidisciplinary team developing an intervention plan based on geriatric assessment.
  • The primary outcome was change in instrumental activities of daily living (IADL) at 3 months; secondary outcomes included mood (GDS), quality of life (FACT-G), and prognostic understanding.

Main Results:

  • The GAIN-S arm showed significant improvements in physical function (IADL, +1.8), mood (GDS, -2.7), and quality of life (FACT-G, +13.2) compared to usual care (P<.001).
  • Patients receiving GAIN-S also experienced reduced symptom burden (ESAS, -14.6) and improved prognostic understanding (P<.01).
  • Clinical characteristics were well-balanced between the 40 patients in each arm.

Conclusions:

  • The telehealth-administered GAIN-S intervention is effective for older adults with cancer in Brazil.
  • These findings highlight the importance of tailored, geriatric assessment-guided interventions for resource-limited settings.
  • GAIN-S offers a scalable model for improving cancer care for older populations.