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  1. Home
  3. Mechanism Of Patulin-induced Renal Injury In Km Mice: An Integrative Approach Combining Network Toxicology, Molecular Docking, And In Vivo Validation.
  1. Home
  3. Mechanism Of Patulin-induced Renal Injury In Km Mice: An Integrative Approach Combining Network Toxicology, Molecular Docking, And In Vivo Validation.

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Mechanism of patulin-induced renal injury in KM mice: An integrative approach combining network toxicology, molecular

Dongmei Xu1, Baigang Zhang2, Chenghui Huang2

  • 1School of Food Engineering, Qingdao Institute of Technology, Shandong, Qingdao, 266300, China; Life Science and Engineering, Lanzhou University of Technology, Gansu, Lanzhou, 730050, China.

Toxicon : Official Journal of the International Society on Toxinology
|June 11, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
ApoptosisMolecular dockingOxidative stressPatulin

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Patulin (PAT) mycotoxin causes kidney damage by disrupting cell death and oxidative stress pathways. This study reveals its molecular mechanisms, offering insights for food safety and therapeutic interventions.

Area of Science:

  • Toxicology
  • Molecular Biology
  • Biochemistry

Background:

  • Patulin (PAT) is a mycotoxin found in moldy foods.
  • PAT causes kidney toxicity, but its mechanisms are unclear.

Purpose of the Study:

  • To elucidate the molecular mechanisms of PAT-induced nephrotoxicity.
  • To establish a model for PAT toxicity and explore therapeutic strategies.

Main Methods:

  • Network toxicology analysis identified key molecular targets and pathways.
  • Molecular docking predicted PAT interactions with renal targets.
  • In vivo experiments assessed PAT effects on kidney function and biomarkers.

Main Results:

  • Network analysis revealed 127 overlapping targets, highlighting apoptosis, oxidative stress, and inflammation.
  • Molecular docking showed strong PAT binding to CASP3 and CASP9.
  • In vivo studies confirmed PAT-induced oxidative stress, apoptosis, mitochondrial dysfunction, and renal damage.

    • Conclusions:

    • PAT induces renal injury through a synergistic interplay of oxidative stress and apoptosis, involving mitochondria-ER crosstalk.
    • Findings provide a basis for PAT safety regulations and potential treatments.
    • A novel methodological framework for mycotoxin toxicity studies was established.