Related Experiment Video

Updated: Jul 22, 2026

Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route
05:35

Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route

Published on: May 31, 2022

2.9K

Exploring microglial replacement: From disease models to clinical translation

Kai Zhou1, Yafeng Wang1, Yiran Xu2

  • 1Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou 450018, China.

Brain, Behavior, and Immunity
|June 11, 2025
PubMed

Insights

Microglial replacement therapy offers a promising approach to renew immune cells in the central nervous system (CNS). This strategy aims to reduce neuroinflammation and treat CNS disorders.

Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Microglia are key immune cells in the central nervous system (CNS), crucial for surveillance, synaptic plasticity, and neuroinflammation.
  • Dysfunctional microglia contribute to various CNS disorders.
  • Microglial replacement therapy is emerging as a strategy to restore CNS health.

Purpose of the Study:

  • To review the current research on microglial replacement therapy for CNS disorders.
  • To highlight preclinical findings on depletion methods, cell sources, and therapeutic impacts.
  • To discuss challenges and considerations for clinical translation.

Main Methods:

  • Literature review of preclinical studies on microglial replacement therapy.
  • Analysis of diverse microglial depletion models.
  • Evaluation of different sources for replaced microglia.
  • Assessment of therapeutic outcomes in CNS disorder models.

Main Results:

  • Preclinical studies demonstrate the feasibility of microglial replacement.
  • Various depletion and repopulation strategies show potential for mitigating CNS pathology.
  • Impacts on neuroinflammation and functional recovery are observed across different models.

Conclusions:

  • Microglial replacement therapy shows significant promise for treating CNS disorders.
  • It offers a novel approach to restore CNS homeostasis and reduce neuroinflammation.
  • Further research and clinical translation are needed to realize its full therapeutic potential.
Keywords:
Gene replacementHSCTIrradiationMicroglial depletionMicroglial repopulation

More Related Videos

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders06:12

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

1.2K
Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions08:47

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

2.0K

Related Concept Videos

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Introduction to Language of Pathophysiology ll01:17

Introduction to Language of Pathophysiology ll

This lesson explores key terms that describe how diseases progress, their outcomes, and their distribution in populations.Diagnostic tests identify diseases and monitor treatment. These include blood and urine tests, biopsies, imaging (X-ray, MRI), and detection of infectious agents.Remission is a reduction or disappearance of symptoms.Exacerbation refers to the worsening of symptoms, such as increased wheezing during an asthma attack.A precipitating factor triggers an acute episode, while a...