Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

310
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
310
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

739
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
739
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Action Potentials01:41

Action Potentials

130.3K
Overview
130.3K
Action Potential01:31

Action Potential

7.9K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
7.9K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.6K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents.

Brain and behavior·2026
Same author

Adult organotypic brain slice cultures recapitulate extracellular matrix remodeling in hemorrhagic stroke.

Frontiers in cellular neuroscience·2026
Same author

The metabolic consequences of evoked spreading depolarization in brain slices.

Scientific reports·2026
Same author

Vascular endothelial growth factor: a double-edged sword in the development of white matter lesions.

Neural regeneration research·2024
Same author

Single-molecule tracking of myelin basic protein during oligodendrocyte differentiation.

Biological imaging·2024
Same author

Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation.

Molecular neurobiology·2023

Related Experiment Video

Updated: Jun 13, 2025

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

6.8K

Plasticity of Myelination.

Grace Flower1, Svenja Vorthmann1, Daniel Fulton2

  • 1Wolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, Guy's Campus, King's College, London, UK.

Advances in Neurobiology
|June 11, 2025
PubMed
Summary

Myelin plasticity allows neural circuits to adapt during learning and recovery. Understanding how neuronal activity shapes myelin offers new therapeutic avenues for neurological diseases.

Keywords:
Activity-dependent myelinationCognition and memoryMyelin dynamicsMyelin plasticityNeuronal circuit adaptationOligodendrocytes

More Related Videos

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

11.0K
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

27.0K

Related Experiment Videos

Last Updated: Jun 13, 2025

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

6.8K
Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

11.0K
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

27.0K

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurobiology

Background:

  • Myelin was historically considered static after development.
  • Emerging evidence shows myelin plasticity is crucial for neural circuit adaptation.
  • This plasticity is vital for learning, memory, and recovery from injury or disease.

Purpose of the Study:

  • To explore the cellular and molecular mechanisms of myelin plasticity.
  • To investigate the role of oligodendrocytes, astrocytes, and microglia in myelin remodelling.
  • To discuss the implications of myelin plasticity in cognition, ageing, and diseases.

Main Methods:

  • Examining activity-dependent and experience-driven myelination.
  • Investigating how neuronal activity regulates oligodendrocyte differentiation and myelin structure.
  • Reviewing experimental models of myelin plasticity.
  • Discussing the role of sleep in myelin maintenance.

Main Results:

  • Neuronal activity dynamically regulates oligodendrocyte function and myelin structure.
  • Myelin plasticity affects neural conduction velocity and circuit synchronization.
  • Changes in myelin impact cognitive functions and disease progression.

Conclusions:

  • Myelin plasticity is a key mechanism for neural adaptation and repair.
  • Understanding myelin plasticity opens potential therapeutic strategies for neurological disorders.
  • Further research into myelin plasticity and maintenance is essential for treating myelin-related diseases.