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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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The role of non-coding RNAs in the regulation of cell death pathways in melanoma

Yekta Metanat1, Maria Sviridova2, Bareq N Al-Nuaimi3

  • 1Faculty of Medicine, Sistan and Baluchestan Province, Zahedan University of Medical Sciences, Zahedan, Iran.

Discover Oncology
|June 11, 2025
PubMed

Insights

Non-coding RNAs (ncRNAs) are key regulators of cell death in melanoma. Understanding their dual role in promoting or preventing cell death offers new avenues for melanoma treatment and biomarker development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Melanoma incidence is rising due to increased UV exposure, with metastatic disease posing significant treatment challenges.
  • Resistance to programmed cell death (PCD) is a critical factor in melanoma progression, affecting survival and therapy resistance.
  • Non-coding RNAs (ncRNAs) are emerging as crucial regulators of biological processes, including various forms of cell death.

Purpose of the Study:

  • To review the diverse roles of ncRNAs in regulating multiple programmed cell death (PCD) pathways in melanoma.
  • To highlight the potential of ncRNAs as diagnostic/prognostic biomarkers and therapeutic targets for melanoma.

Main Methods:

  • Literature review of studies investigating ncRNAs and programmed cell death (PCD) in melanoma.
  • Analysis of ncRNA involvement in apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis, and anoikis.
  • Synthesis of current knowledge on ncRNA functions in melanoma progression and treatment resistance.

Main Results:

  • ncRNAs exhibit a dual role in melanoma, either promoting tumor survival by inhibiting PCD or acting as anti-tumor agents by inducing it.
  • Specific ncRNAs are implicated in regulating distinct PCD pathways, influencing melanoma cell fate.
  • The complex regulatory network of ncRNAs in PCD presents opportunities for targeted melanoma therapies.

Conclusions:

  • ncRNAs are pivotal in controlling programmed cell death (PCD) in melanoma, impacting tumor behavior.
  • Targeting ncRNAs involved in PCD offers promising strategies for novel melanoma diagnostics and therapeutics.
  • Further research into ncRNA-mediated PCD regulation is essential for advancing melanoma treatment.
Keywords:
Cancer biomarkersMelanomaNcRNA dysregulationNon-coding RNAsProgrammed cell death

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