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Updated: Jun 13, 2025
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Association between ABO blood groups and pancreatic cancer outcomes: A systematic review and meta-analysis
Tulio L Correa1, Mario Keko1, Pedro Danielian2
1Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Background/Objectives:
Although some studies report an increased overall survival for patients with pancreatic cancer and blood type O, others show no significant association. Therefore, we sought to perform a systematic review and meta-analysis to evaluate the association between ABO blood groups and the outcomes of patients with pancreatic cancer.
Methods:
A systematic review of the literature was conducted using the PubMed/Medline, Cochrane Library, and Embase databases in April 2024. This review included observational studies that assessed pancreatic cancer outcomes regarding different ABO blood groups. The outcomes of interest included overall survival (OS), median survival time, tumor stage, lymph node metastasis, and distant metastasis.
Results:
A total of 18 studies were included in this systematic review, encompassing 9084 patients. The mean age of patients was 62.6 ± 36.5 years old and the proportion of males was 58.8 % (n = 4177). Blood type O showed better OS than non-O in both unadjusted (HR 0.82; 95 % CI 0.75-0.91) and adjusted analyses (HR 0.76; 95 % CI 0.68-0.85). Blood type O patients were also less frequently diagnosed with advanced disease stages upon presentation (OR 0.82; 95 % CI 0.69-0.97). There were no statistically significant differences in either lymph node metastasis or distant metastasis.
Conclusions:
Patients with blood type O exhibited better OS and were less frequently diagnosed with advanced cancer stages (III-IV) upon presentation compared to those with non-O blood types. Further research is needed to investigate the mechanisms underlying these associations.
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