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Exosome-mediated regulation of macrophage polarization: A novel therapeutic strategy for diabetic wound healing

Jia-Le Ma1, Ling-Xiao Wang2, Hao Yu1

  • 1Department of Plastic Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|June 11, 2025
PubMed
Abstract

No abstract available in PubMed .

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Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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