Advanced Oral Delivery Systems for Nutraceuticals.

Area of Science:

• Nutraceutical Science
• Materials Science
• Drug Delivery Systems

Background:

• Oral administration is preferred for nutraceuticals due to convenience, but bioavailability is limited by poor solubility, instability, and first-pass metabolism.
• Traditional carriers like proteins, lipids, and carbohydrates have inherent limitations in overcoming these bioavailability challenges.

Purpose of the Study:

• To review current and emerging oral delivery platforms for nutraceuticals.
• To highlight strategies for overcoming bioavailability barriers and enhancing nutraceutical efficacy.
• To compare traditional and novel delivery systems, outlining design principles for optimization.

Main Methods:

• Literature review of traditional carriers (proteins, lipids, carbohydrates).
• Exploration of advanced material science platforms: biodegradable polymers, metal-organic frameworks (MOFs), metal-polyphenol networks (MPNs).
• Investigation of 3D printing technologies, including integration with artificial intelligence (AI) for precision nutrition.

Main Results:

• Biodegradable polymers enhance stability and control release.
• MOFs provide high surface area for encapsulating sensitive compounds.
• MPNs offer biocompatible, stimuli-responsive delivery, while 3D printing enables personalized systems with precise control.

Conclusions:

• Novel platforms significantly improve nutraceutical stability, solubility, and targeted delivery.
• Advanced oral delivery systems, including AI-integrated 3D printing, hold transformative potential for personalized nutrition.
• Optimized delivery systems are crucial for improving bioavailability and therapeutic outcomes of nutraceuticals.