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Updated: Jun 13, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Highly enantioselective hydrogenation of 2-pyridyl ketones enabled by Ir-f-phamidol catalyst
Lei Xu1, Gen-Qiang Chen2, Xumu Zhang1,2,3
1Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, and Medi-Pingshan, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen 518055, China.
Abstract:
Herein, we report a highly efficient and enantioselective Ir-f-phamidol catalysed hydrogenation of 2-pyridyl ketones, enabling the synthesis of chiral pyridyl-substituted secondary alcohols with exceptional enantioselectivity (up to >99% ee) and remarkable catalytic efficiency (S/C up to 10 000). The broad substrate scope, high efficiency and enantioselectivity, mild conditions, and successful gram-scale demonstration of this reaction highlight a significant advancement in chiral alcohol synthesis and underscore its practicality and industrial relevance.
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