Prostate artery EmbolisAtion Safety and efficacY: Preliminary and foLlow-Up urodynamic Studies (P-EASY PLUS)

Area of Science:

• Urology
• Interventional Radiology

Background:

• Benign prostatic hyperplasia (BPH) is a common condition causing lower urinary tract symptoms.
• Obstructive BPH significantly impacts quality of life and requires effective management strategies.

Purpose of the Study:

• To evaluate the efficacy of prostate artery embolisation (PAE) in managing obstructive BPH.
• To assess improvements using urodynamic studies and patient-reported outcomes.

Main Methods:

• 105 patients with symptomatic BPH underwent PAE.
• Baseline and 18-month follow-up assessments included urodynamic studies, International Prostate Symptom Scores (IPSS), and Quality of Life (QoL) scores.
• Prostate volume and urinary flow rates were also measured.

Main Results:

• PAE led to a 30.6% reduction in prostate volume and significant improvements in IPSS (55% decrease) and QoL scores (65.9% improvement).
• Urodynamic parameters showed increased maximum urinary flow rate and decreased detrusor pressure, with bladder obstruction rates falling from 66.7% to 29.8%.
• The procedure was well-tolerated with minimal complications and a low rate of retrograde ejaculation (2%).

Conclusions:

• PAE demonstrates significant subjective and objective improvements in managing obstructive BPH.
• These findings support PAE as a viable non-surgical treatment option for symptomatic BPH.
• Further long-term studies are warranted to confirm sustained efficacy.